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Dr. A. K. Nangia

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Director NCL
Director : Director Office

+91-20-25902600 +91-20-25902601

ak.nangia@ncl.res.in

Dr. Nangia's Home Page

MY AREAS OF EXPERTISE

Crystal Engineering, Polymorphs and Cocrystals, Solid-state Pharmaceuticals

MY RESEARCH INTERESTS

 

Crystal Engineering, Supramolecular Chemistry

Supramolecular chemistry is chemistry beyond the molecule. Conventional chemistry deals with covalent bonds while supramolecular chemistry examines the weaker and reversible non-covalent interactions like hydrogen bonding, metal coordination, hydrophobic forces, van der Waals forces, p-p interactions and electrostatic effects between the molecules. The study of non-covalent interactions has got immense importance in biological systems. Crystal engineering is defined as the understanding of intermolecular interaction in the context of crystal packing and in the utilization of such understanding in the design of new solids with desired physical and chemical properties. Crystal engineering is the construction of crystalline materials from molecules or ions using non-covalent interactions. It deals with the self assembly of both organic and inorganic system: molecular crystals, nanostructures metal-organic frameworks and coordination polymers.

Host–guest Compounds, Hydrogen Bonding

The inclusion of small guest molecules in open framework of a host molecule constitutes a host guest compound. Cavitands, or molecular host compounds with intra-molecular cavities; Clathrands are hosts with extra-molecular cavities that result from the aggregation of more than one molecule are two major categories of host guest chemistry. The rational construction of novel open-framework of organic solids is of particular interest because of their diverse applications such as chemical separation, reactions and catalysis in a microcavity, and for electro-optic, nonlinear and magnetic materials. Metal-ligand coordination bonding is extensively used in the modular assembly of extended porous solids and low density frameworks. Tuning the pore size and shape and controlling the hydrophobic/hydrophilic nature of the host cavity are major endeavors in crystal engineering.

Polymorphism, Cocrystals, Eutectics

The ability of a molecule to crystallize in different crystalline forms is known as polymorphism. Polymorphism in organic solids is of fundamental importance because of its ability to alter physical and chemical properties in different crystal structures, such as melting point, density, compressibility, solubility, hardness, dipole moment and bioavailability. Understanding the origin of polymorphism and controlling the outcome of crystallization process to avoid undesired forms is a current goal in crystal engineering. Getting the right polymorph is not only important for drugs and pharmaceuticals but also for chemicals like explosives, dyes, pigments, flavors and confectionery products. This approach enables emerging strategies to speed-up pharmaceutical development and capture solid form diversity of pharmaceutical substances.

Analytical and Diffraction Techniques for Solid-state Characterization

Improved Medicines and Pharmaceutical Formulation

ACADEMIC QUALIFICATION

 

Ph.D. ,  (1998)

Yale University, New Haven, USA

M.Sc. Chemistry ,  (1983)

I.I.T. Kanpur

PROFESSIONAL EXPERIENCE

 

CSIR - National Chemical LaboratoryPune

Director
2016-Present

University of HyderabadHyderabad

Professor
2001-2016

University of HyderabadHyderabad

Reader
1993-2001

University of HyderabadHyderabad

Lecturer
1989-1993

NOCIL, Agrochemicals R&DNavi Mumbai

Research
1988-1989

PUBLICATIONS

 

Multicomponent ternary cocrystals of the sulfonamide group with pyridine-amides and lactams.

Chemical Communications  (2015)
Dr. Ashwini Nangia

Eutectics as Improved Pharmaceutical Materials: Design, Properties and Characterization

Chemical Communications  (2014)
Dr. Ashwini Nangia

AWARDS & HONORS

 

JC Bose National Fellowship, DST, New Delhi

2010

Fellow, Indian National Science Academy, New Delhi

2009

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