Mahesh Jagdishrao Kulkarni

Dr. Mahesh J Kulkarni

Scientist : Biochemical Sciences Division

Dr. Kulkarni's Home Page
+91-20-25902541
+91-20-25902648
mj.kulkarni@ncl.res.in

MY AREAS OF EXPERTISE
Analytical Chemistry, BioTechnology, Chemical Biology, Proteomics

MY RESEARCH INTERESTS
 

Mass spectrometry, Proteomics, Diabetes, Chemical Biology

Diabetes and its associated complications are becoming global public health problems and posing a serious challenge in disease management. Advanced Glycation End products (AGEs) are implicated in development of insulin resistance, as well as in pathogenesis of diabetic complications. In this context, we have developed methods to quantify plasma AGEs, identified risk factors for elevated plasma AGEs, discovered drug molecules that have the potential to be repositioned as glycation inhibitors, and identified the molecular mechanism for glycation induced formation of protease resistant proteins. The long-term goal is to identify diagnostic markers for various diabetic complications, identify drug targets and develop intervention strategies.

ACADEMIC QUALIFICATION
 
PhD Crop Physiology,  (2002)
University Of Agricultural Sciences, Bangalore

PROFESSIONAL EXPERIENCE
 
CSIR-National Chemical LaboratoryPune
Scientist
2004-Present

Genome InstituteSingapore
Post Doctoral Fellow
2004-2004

PUBLICATIONS
 
Proteomic analysis of protease resistant proteins in the diabetic rat kidney
Molecular and Cellular Proteomics  (2013)
Dr. Ashok Giri, Dr. Mahesh Kulkarni, Bansode S.B., Joshi R.S., Harsulkar A.M., Bodhankar S.L., Chougale A.D.

A novel mechanism for antiglycative action of limonene through stabilization of protein conformation
Molecular BioSystems  (2013)
Dr. Mahesh Kulkarni, Arvindekar A.U., Joglekar M.M., Chougale A.D., Panaskar S.N.

AWARDS & HONORS
 
Member of Editorial Board, Clinical Proteomics 2018

Chellaram Diabetes Institute Special Recognition Award at International Diabetes Summit 2018

PATENTS
 
Method for identifying and quantifying carboxyethyl valine modified haemoglobin US20170074888 A1
Kulkarni MJ, Jagadeeshaprasad MG, Batkulwar KB, Fernandes M

RESEARCH GROUP

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