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Dr. Mahesh J Kulkarni

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Scientist : Biochemical Sciences Division

+91-20-25902541 +91-20-25902648

mj.kulkarni@ncl.res.in

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MY AREAS OF EXPERTISE

Analytical Chemistry, Bioinformatics, BioTechnology, Chemical Biology, Proteomics

MY RESEARCH INTERESTS

 

Mass spectrometry, Proteomics, Diabetes, Chemical Biology

Diabetes and its associated complications are becoming global public health problems and posing a serious challenge in disease management. Advanced Glycation End products (AGEs) are implicated in development of insulin resistance, as well as in pathogenesis of diabetic complications. In this context, we have developed methods to quantify plasma AGEs, identified risk factors for elevated plasma AGEs, discovered drug molecules that have the potential to be repositioned as glycation inhibitors, and identified the molecular mechanism for glycation induced formation of protease resistant proteins. The long-term goal is to identify diagnostic markers for various diabetic complications, identify drug targets and develop intervention strategies.

ACADEMIC QUALIFICATION

 

PhD Crop Physiology,  (2002)

University Of Agricultural Sciences, Bangalore

PROFESSIONAL EXPERIENCE

 

CSIR-National Chemical LaboratoryPune

Scientist
2004-Present

PUBLICATIONS

 

Molecular Investigations of Protriptyline as a Multi-Target Directed Ligand in Alzheimer's Disease

PLoS ONE  (2014)
Dr. Mahesh Kulkarni, Dr.(Ms.) Neelanjana Sengupta, Warkad, SD, Batkulwar, KB, Jana, AK, Joshi, RS, Bansode, SB, Kulkarni, MJ

Proteomics of arsenic stress in the gram-positive organism Exiguobacterium sp PS NCIM 5463

Applied Microbiology and Biotechnology  (2014)
Dr. Mahesh Kulkarni, Patil, R, Bhonsle, H, Dube, A, Gade, W, Marathe, S, Rapole, S, Sacheti, P, Thombre, D, Vidhate, R, Wagh, P

AWARDS & HONORS

 

NCL Research Foundation - Scientist of the year

2010

Young Associate of Maharashtra Academy of Sciences

2007

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CSIR- National Chemical Laboratory (NCL)
Dr. Homi Bhabha Road, Pune- 411008, India. Tel. :+91-20-2590 2000, 25893400;
Fax :+91-20-2590 2660.

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